Publications 2014

O’Donoghue, P., Prat, L., Kucklick, M., Schäfer, J.G., Riedel, K., Rinehart, J., Söll, D. and Heinemann, I.U. (2014) Reducing the genetic code induces massive rearrangement of the proteome. Proc. Natl. Acad. Sci. USA 111. Abstract

Guo, L-T., Wang, Y-S., Nakamura, A., Eiler, D., Kavran, J., Wong, M., Kiessling, L.L., Steitz, T., O’Donoghue, P. and Söll, D. (2014) Polyspecific pyrrolysyl-tRNA synthetases from directed evolution. Proc. Natl. Acad. Sci. USA 111, 16724-16729. Abstract

Haruna, K-I., Alkazemi, M.H., Liu, Y., Söll, D. and Englert, M. (2014) Engineering the elongation factor Tu for efficient selenoprotein synthesis. Nucl. Acids Res. 42, 9976-9983. Abstract

Liu,Y., Nakamura, A., Nakazawa, Y., Asano, N., Ford, K.A., Hohn, M.J., Tanaka, I., Yao, M. and Söll, D. (2014) An ancient translation factor is essential for tRNA-dependent cysteine biosynthesis in methanogenic archaea. Proc. Natl. Acad. Sci. USA 111, 10520-10525. Abstract

Fan, C., Ho, J.M.L., Chirathivat, N., Söll, D. and Wang, Y-S. (2014) Exploring the substrate range of wild-type aminoacyl-tRNA synthetases. ChemBioChem 15, 1805-1809. Abstract

Chavarria, N.E., Cao, S., Holman, M., Elbanna, D., Rodriguez, S., Arrington, D., Englert, M., Uthandia, S., Söll, D. and Maupin-Furlow, J.A. (2014) Ncs6/Tuc1 homolog (NcsA) is required for tRNALysUUU thiolation and is associated with ubiquitin-proteasome and RNA processing system homologs in Archaea. PLoS ONE 9(6): e99104. Abstract

Zhang, X., Ling, J., Barcia, G., Jing, L., Barry, B.J., Partlow, J.N., Weimer, J.M., Stein, Q., Poduri, A., Ville, D., Dulac, O., Mochida, G.H., Hill, R.S., Yu, T.W., Lam, A-T.N., Servattalab, S., Rodriguez, J., Boddaert, N., Munnich, A., Colleaux, L., Zon, L.I., Söll, D., Walsh, C.A. and Nabbout, R. (2014) Mutations in QARS, encoding glutaminyl-tRNA synthetase, cause progressive microcephaly, cerebral-cerebellar atrophy, and intractable seizures. Am. J. Hum. Genet. 94, 547-558. Abstract

Liu, Y., Long, F., Wang, L., Söll, D. and Whitman, W.B. (2014) The putative tRNA 2-thiouridine synthetase Ncs6 is an essential sulfur carrier in Methanococcus maripaludis. FEBS Lett. 588, 873-877. Abstract

Itoh, Y., Bröcker, M.J., Sekine, S-I., Söll, D. and Yokoyama, S. (2014) Dimer-dimer interaction of the bacterial selenocysteine synthase SelA promotes functional active site formation and catalytic specificity. J. Mol. Biol. 426, 1723-1735. Abstract

Mandal, D., Köhrer, C., Su, D., Babu, I.R., Chan, C.T.Y., Liu, Y., Söll, D., Blum, P., Kuwahara, M., Dedon, P.C., and RajBhandary, U.L. (2014) Identification and codon reading properties of 5-cyanomethyl uridine, a new modified nucleoside found in the anticodon wobble position of mutant haloarchaeal isoleucine tRNAs. RNA 20, 177-188. Abstract

Bröcker, M.J., Ho, J.M.L., Church, G.M., Söll, D. and O’Donoghue, P. (2014) Recoding the genetic code with selenocysteine. Angew. Chem. Int. Ed. 53, 319-323. Abstract

Bröcker, M.J., Ho, J.M.L., Church, G.M., Söll, D. and O’Donoghue, P. (2014) Umkodierung des genetischen Codes mit Selenocystein. Angew. Chem. 126, 325-330. Abstract

Ling, J., Daoud, R., LaJoie, M.J., Church, G.M., Söll, D. and Lang, B.F. (2014) Natural reassignment of CUU and CUA sense codons to alanine in Ashbya mitochondria. Nucl. Acids Res. 42, 499-508. Abstract