Research in the Söll laboratory covers a broad range of topics unified by a single problem – evolution of the genetic code. We explore the genetic code translation in a wide range of living species. Through genetics, biochemistry, structural analysis, and molecular biology, we are studying bacterial, archaeal and eukaryotic systems to uncover new strategies of genetic code expression. We extensively use this knowledge to develop new tools for synthetic biology and extend the chemistry of living systems by enabling robust and efficient genetic encoding of unnatural amino acids and amino acid-like molecules in a test tube and in a living cell.

To learn more about the Söll laboratory research, please visit the Research page.


January 22, 2019
 Molecular Biology and Evolution journal has released a new cover (January 2019) that features an evolutionary study by Söll lab’s postdoc Sergey Melnikov and a former...
August 1, 2018
Dieter Söll Lab welcomes a new postdoctoral associate, Jeffery Tharp. Jeffery has recently graduated from Department of Chemistry at Texas A&M University (Wenshe Liu lab...
July 15, 2018
Noah Reynolds, Dieter Söll Lab postdoctoral associate, will leave the lab to take a job of an assistant professor at University of Illinois at Springfield. Congratulations...