Research in the Söll laboratory covers a broad range of topics unified by a single problem – evolution of the genetic code. We explore the genetic code translation in a wide range of living species. Through genetics, biochemistry, structural analysis, and molecular biology, we are studying bacterial, archaeal and eukaryotic systems to uncover new strategies of genetic code expression. We extensively use this knowledge to develop new tools for synthetic biology and extend the chemistry of living systems by enabling robust and efficient genetic encoding of unnatural amino acids and amino acid-like molecules in a test tube and in a living cell.

To learn more about the Söll laboratory research, please visit the Research page.


November 12, 2017
Last January Corwin Miller finished his postdoctoral training at Soll Lab to start a pharmaceutical company focused on developing new medicine. Recently, in a study published...
October 19, 2017
An interdisciplinary team of Yale researchers, including Söll lab, is celebrating a $1.8 million grant award from the National Science Foundation. This award will be used to...
October 17, 2017
A new study by the Söll lab in cooperation with David Liu’s lab at Harvard reveals the structure of an elusive functional domain of pyrrolysyl-tRNA synthetase, an...