Research in the Söll laboratory covers a broad range of topics unified by a single problem – evolution of the genetic code. We explore the genetic code translation in a wide range of living species. Through genetics, biochemistry, structural analysis, and molecular biology, we are studying bacterial, archaeal and eukaryotic systems to uncover new strategies of genetic code expression. We extensively use this knowledge to develop new tools for synthetic biology and extend the chemistry of living systems by enabling robust and efficient genetic encoding of unnatural amino acids and amino acid-like molecules in a test tube and in a living cell.

To learn more about the Söll laboratory research, please visit the Research page.


October 6, 2016
Humans need eight essential trace elements for good health, and one of them is selenium – a powerful antioxidant that is important for thyroid and brain function as well as...
Chenguang Fan
July 26, 2016
After four years of postdoctoral research at the Söll lab, Chenguang Fan accepted Assistant Professor position at the Department of Chemistry and Biochemistry at University...
Genetic code.
May 1, 2016
In the journal Angewandte Chemie International Ed., researchers from the US Department of Energy Joint Genome Institute (DOE JGI), a DOE Office of Science User Facility, and...